Nearly 4 years since the first messenger RNA (mRNA) COVID-19 vaccines were developed, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is evolving more quickly than tailored boosters can be made ready and continues to kill hundreds of Americans every week. Scientists around the world have been trying to break new ground with the next generation of vaccines, but the unprecedented speed and collaboration with which those first mRNA shots were developed and made available to the public have not been replicated.
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